ICONA® Pn

Polynucleotide

What is it

ICONA® Pn RANGE: ADVANCED POLYNUCLEOTIDE SYSTEM FOR FULL-SPECTRUM SKIN REJUVENATION

The ICONA® Pn Range is a professional-grade injectable suite designed to support skin quality, structural integrity, and dermal revitalisation across the face, body, eyes, and scalp — without altering shape or adding volume.

Powered by proprietary R³ Regenerative Technology, each Pn formulation combines high-purity polynucleotides with specialised co-factors. The formulations are engineered to support collagen-associated biological pathways, optimise extracellular matrix function, and contribute to long-term tissue quality improvement within the dermal environment.

Developed by Gill Pharmaceuticals Ltd, the ICONA® Pn Range reflects a commitment to clinically driven innovation — offering medical professionals a versatile, non-volumising bio-stimulatory platform intended to enhance aesthetic skin quality across multiple anatomical zones.

This information is provided for medical professionals seeking an overview of formulation design and intended biological interaction.

THE BENEFITS OF ICONA® Pn

Key Advantages of the Product

MULTI-ZONE POLYNUCLEOTIDE FORMULAS
Each ICONA® Pn product is precisely formulated for its intended treatment zone — face, body, eyes, or scalp. With targeted concentrations of polynucleotides and specialised co-factors, the range provides medical professionals with a versatile bio-stimulatory solution tailored to the differing structural and aesthetic requirements of each anatomical area.
R³ REGENERATIVE TECHNOLOGY™
Powered by R³ Technology™, ICONA® Pn is designed to support tissue quality improvement across multiple indications. This structured three-phase framework — Repair, Restore, Reinforce — reflects a formulation philosophy focused on supporting dermal structure, enhancing elasticity, and optimising the extracellular environment over time.
NATURAL, NON-VOLUMISING OUTCOMES
Designed for subtle yet clinically meaningful aesthetic improvement, ICONA® Pn supports improvements in skin texture, hydration, and overall skin quality without adding volume or altering facial structure. Patients may experience visible enhancements with minimal downtime, making the range well suited to natural-look rejuvenation protocols.

How It Works

TARGETED DERMAL PLACEMENT SUPPORTING BIO-STIMULATORY SKIN QUALITY IMPROVEMENT ACROSS MULTIPLE ANATOMICAL ZONES

ICONA® Pn injectables are administered via precise micro-injection techniques into targeted dermal planes, selected according to the treatment area — including facial, body, periocular, and scalp applications. This controlled placement approach is designed to optimise local dermal availability while supporting tissue tolerance and minimising procedural downtime.

Depending on clinical indication, micro-bolus or mesotherapy techniques may be employed to introduce the polynucleotide-based formulation into the extracellular matrix. Within the dermal environment, the formulation is designed to support fibroblast-associated activity, contribute to collagen- and elastin-related structural processes, assist in maintaining dermal hydration, and promote a tissue environment associated with long-term skin quality improvement — without altering volume or facial structure.

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Key Ingredients & Technology

FORMULATION AND INNOVATION EXPLAINED

Explore the key formulation components and technology underpinning the ICONA® Pn range. Each formulation is precisely engineered to support skin quality improvement and tissue integrity without volumisation, with zone-specific design considerations to optimise aesthetic performance across different anatomical areas.

Polynucleotides (40mg/ml)
High-purity, high-strength polydeoxyribonucleotide chains derived from salmonid DNA, designed to support fibroblast-associated activity and extracellular matrix integrity, contributing to progressive, visible dermal skin-quality improvement.
Hyaluronic Acid (20mg/ml)
Non-crosslinked, ultra-pure HA provides deep hydration and matrix support — boosting elasticity and plumpness without altering facial structure.
R³ Technology™
A proprietary 3-phase regenerative mechanism:
• Repair — Cellular activation
• Restore — Collagen and elastin support
• Reinforce — ECM hydration and resilience

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Polynucleotides (20mg/ml)
Moderate-strength polydeoxyribonucleotide chains derived from salmonid DNA, designed for use across larger dermal areas to support fibroblast-associated activity and contribute to improvements in skin tone, texture, and overall structural resilience over time.
Hyaluronic Acid (20mg/ml)
Hydrating support for skin elasticity and smoothness in body zones prone to laxity or scarring.
R³ Technology™
Tri-phase action focused on deeper dermal restoration for crepey or damaged body skin.

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Polynucleotides (15mg/2ml)
Lower-dose polydeoxyribonucleotide chains derived from salmonid DNA, formulated in a hyaluronic acid–based hydrogel matrix and physiological buffer solution, designed for use in delicate periocular tissue to support gradual dermal skin-quality improvement, including a more resilient appearance, refined texture, and improved skin tone over time.
Amino Acid Complex
Supports cellular repair and microcirculation in the periorbital region.
Carnosine
A potent antioxidant and anti-glycation peptide that protects against free radical and environmental stressors.
R³ Technology™
Gentle, layered repair designed for the delicate eye area.

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Polynucleotides (15mg/ml)
Polydeoxyribonucleotide chains derived from salmonid DNA, formulated in a hyaluronic acid–based hydrogel matrix and physiological buffer solution, designed to support scalp skin quality and extracellular matrix integrity, helping to support the peri-follicular tissue environment over time.
Oligopeptides (10mg/ml)
Biomimetic peptides that stimulate dermal activity, enhance microcirculation, and may prolong the anagen phase of hair growth.
Amino Acids
Essential building blocks for healthy hair growth and skin structure.
R³ Technology™
Activates dermal papilla function and reinforces scalp matrix integrity.

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The Result

Visible Outcomes and Proven Effectiveness

Improved Skin Density and Structure
Tissue appears stronger, more compact, and visibly firmer — reflecting improved ECM integrity and fibroblast activity.
Natural-Looking Rejuvenation
Restores skin quality without volume or puffiness. Results are subtle, progressive, and designed to enhance—not alter—facial identity.
Refined Texture and Tone
Surface becomes noticeably smoother and more uniform, with reduced roughness, fine lines, and early creping.
Hydrated, Balanced Skin Appearance
Skin feels more hydrated and resilient, with reduced dryness and improved barrier function from the inside out.