The Science Behind A.R.T. Technology®

Inside the Innovation:

The Science of ICONA

At the heart of ICONA® lies A.R.T. Technology® (Advanced Regenerative Technology) — a proprietary innovation from Gill Pharmaceuticals that blends cutting-edge formulation science with skin biology. The result? A smarter, more effective way to support skin regeneration at a cellular level.

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Key Scientific Features of A.R.T. Technology®

Scientific Basis:

  • A.R.T. Technology® adjusts pH, ionic balance, and osmolarity to optimise the intradermal retention and cellular uptake of actives.
  • Vitamin C is stabilised in a non-oxidative buffered form, improving penetration and intracellular delivery to fibroblasts.
  • Amino acids are delivered in a L-isomeric, bioactive configuration that mimics natural dermal substrates, ensuring efficient utilisation.

Pharmacological Effect:

  • Enhanced uptake at the dermo-epidermal junction.
  • More efficient triggering of collagenesis and antioxidative responses.
  • Avoidance of systemic diffusion, retaining actives at the target site.

Scientific Basis:

  • ICONA® H8 contains a controlled ratio of high molecular weight (HMW) and low molecular weight (LMW) hyaluronic acid.
  • A.R.T. Technology® utilises a matrix-based stabilisation method that preserves molecular weight integrity during sterilisation and storage.

Pharmacological Effect:

  • HMW HA (~1,000–1,500 kDa) remains in the superficial dermis, forming a hydrating film that:
  • Reduces transepidermal water loss (TEWL)
  • Improves tactile skin smoothness
  • Acts as an anti-inflammatory modulator

LMW HA (~50–200 kDa) penetrates deeper into the dermis where it:

  • Activates fibroblast CD44 and RHAMM receptors
  • Stimulates endogenous HA, collagen, and elastin synthesis
  • Triggers dermal remodelling via MMP and TGF-β signalling

Scientific Basis:

  • Nutrient synergy is engineered to mimic wound healing microenvironments.
  • Combination of HA, L-amino acids, and buffered vitamin C induces controlled regenerative signalling rather than inflammation.

Pharmacological Effect:

  • Upregulation of fibroblast growth factor (FGF) and transforming growth factor-beta (TGF-β) cascades
  • Activation of matrix metalloproteinases (MMP-1, MMP-3) for controlled ECM turnover
  • Encourages keratinocyte migration and angiogenesis for enhanced skin texture and tone

Scientific Basis:

  • Isotonic, non-immunogenic formulation with human-skin-compatible pH (~6.8–7.2)
  • Free from cross-linking agents (e.g. BDDE), parabens, and animal-derived proteins

Pharmacological Effect:

  • Low incidence of post-injection adverse events (erythema, oedema, hypersensitivity)
  • Safe for repeat use in sensitive or compromised skin, including post-laser or microneedling
  • Does not provoke immune activation or granuloma formation

Formulated by Science.

Driven by Results.

The Result? A regenerative injectable that works in harmony with your skin — not against it. The ICONA® range powered by A.R.T. Technology® delivers science-backed results with clinical precision and natural elegance.

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